Goldstein et al study: Increased risk of RSV hospitalization in the 2014-2016 seasons vs the 2012-2014 seasons¹  ²

A study examining risk of RSV hospitalization in preterm infants in the 2014-2016 and 2012-2014 RSV seasons

Study Design

Data Source

MarketScan Commercial Claims and Multistate Medicaid databases

Patient Selection Criteria

Infants <1 year CA between July 1, 2011, and June 30, 2016

Included

  • Preterm infants born 29-34 wGA
  • Full-term infants without health problems
  • Commercially insured infants born 29-34 wGA, n=33,667
  • Commercially insured infants born full term, n=668,619
  • Medicaid-insured infants born 29-34 wGA, n=51,439
  • Medicaid-insured infants born full term, n=908,594

Excluded

  • Preterm and full-term infants with CLDP, CHD, or other special conditions, such as:
    • Cystic fibrosis
    • Immunodeficiency
    • Congenital anomalies of respiratory system
    • Neuromuscular, immunological, or genetic conditions
    • Organ transplants

Outcomes Evaluated

RSV hospitalizations were examined using ICD-9-CM and ICD-10-CM codes

ICD-9-CM CODES

ICD-10-CM CODES

RSV infection (079.6) RSV as the cause of diseases classified elsewhere (B974 and J205)
RSV bronchiolitis (466.11) RSV pneumonia (J121)
RSV pneumonia (480.1) Acute bronchiolitis due to RSV (J210)

 

Rate ratios were defined as preterm infant risk relative to full-term infant risk

Study Limitations

RSV hospitalizations were identified using ICD-9-CM and ICD-10-CM diagnosis codes on inpatient claims; confirmatory laboratory results were not available

Risk of RSV Hospitalization

When compared to full-term infants, the risk of RSV hospitalization was significantly greater in commercially insured preterm infants 29-34 wGA and <6 months CA in the 2014-2016 seasons vs the 2012-2014 seasons

 

When compared to full-term infants, the risk of RSV hospitalization was significantly greater in Medicaid-insured preterm infants 29-34 wGA and <6 months CA in the 2014-2016 seasons vs the 2012-2014 seasons

Summary

Goldstein et al conclusions:

  • When compared to full-term infants, the risk of RSV hospitalization was significantly greater in commercially insured and Medicaid-insured preterm infants 29-34 wGA and <6 months CA in the 2014-2016 seasons vs the 2012-2014 seasons
  • 2x greater in commercially insured infants
  • 1.5x greater in Medicaid-insured infants

References

  1. Goldstein M, Krilov LR, Fergie J, et al. Poster presented at: Academy of Managed Care Pharmacy Nexus; October 16-19, 2017; Dallas, TX.

  2. Data on file, REF-23618, AstraZeneca Pharmaceuticals LP.

RSV=respiratory syncytial virus; CA=chronological age; wGA=weeks gestational age; CLDP=chronic lung disease of prematurity; CHD=congenital heart disease; CI=confidence interval.

Goldstein et al study: Increased risk of RSV hospitalization in the 2014-2016 seasons vs the 2012-2014 seasons¹  ²

A study examining risk of RSV hospitalization in preterm infants in the 2014-2016 and 2012-2014 RSV seasons

Study Design

Data Source

MarketScan Commercial Claims and Multistate Medicaid databases

Patient Selection Criteria

Infants <1 year CA between July 1, 2011, and June 30, 2016

Included

  • Preterm infants born 29-34 wGA
  • Full-term infants without health problems
  • Commercially insured infants born 29-34 wGA, n=33,667
  • Commercially insured infants born full term, n=668,619
  • Medicaid-insured infants born 29-34 wGA, n=51,439
  • Medicaid-insured infants born full term, n=908,594

Excluded

  • Preterm and full-term infants with CLDP, CHD, or other special conditions, such as:
    • Cystic fibrosis
    • Immunodeficiency
    • Congenital anomalies of respiratory system
    • Neuromuscular, immunological, or genetic conditions
    • Organ transplants

Outcomes Evaluated

RSV hospitalizations were examined using ICD-9-CM and ICD-10-CM codes

ICD-9-CM CODES

ICD-10-CM CODES

RSV infection (079.6) RSV as the cause of diseases classified elsewhere (B974 and J205)
RSV bronchiolitis (466.11) RSV pneumonia (J121)
RSV pneumonia (480.1) Acute bronchiolitis due to RSV (J210)

 

Rate ratios were defined as preterm infant risk relative to full-term infant risk

Study Limitations

RSV hospitalizations were identified using ICD-9-CM and ICD-10-CM diagnosis codes on inpatient claims; confirmatory laboratory results were not available

Risk of RSV Hospitalization

When compared to full-term infants, the risk of RSV hospitalization was significantly greater in commercially insured preterm infants 29-34 wGA and <6 months CA in the 2014-2016 seasons vs the 2012-2014 seasons

 

When compared to full-term infants, the risk of RSV hospitalization was significantly greater in Medicaid-insured preterm infants 29-34 wGA and <6 months CA in the 2014-2016 seasons vs the 2012-2014 seasons

Summary

Goldstein et al conclusions:

  • When compared to full-term infants, the risk of RSV hospitalization was significantly greater in commercially insured and Medicaid-insured preterm infants 29-34 wGA and <6 months CA in the 2014-2016 seasons vs the 2012-2014 seasons
  • 2x greater in commercially insured infants
  • 1.5x greater in Medicaid-insured infants

References

  1. Goldstein M, Krilov LR, Fergie J, et al. Poster presented at: Academy of Managed Care Pharmacy Nexus; October 16-19, 2017; Dallas, TX.

  2. Data on file, REF-23618, AstraZeneca Pharmaceuticals LP.

RSV=respiratory syncytial virus; CA=chronological age; wGA=weeks gestational age; CLDP=chronic lung disease of prematurity; CHD=congenital heart disease; CI=confidence interval.