Goldstein et al: Among infants <29 wGA, RSV-related hospitalizations have increased since 20141

This study evaluated the risk of RSV hospitalization among infants <29 wGA since 2014¹

Data Source

IBM Watson Health MarketScan® Commercial Claims and Encounters (commercial) and
Medicaid Multi-State (Medicaid) databases 

Patient Identification

Infants <12 months between July 1, 2012, and June 30, 2016

Included

  • Otherwise healthy infants born at <29 wGA
  • Full-term infants without major health problems

Commercially insured infants
<3 months CA
<29 wGA n=1,157; Term n=313,676

3-<6 months CA
<29 wGA n=2,152; Term n=329,770

6-<12 months CA
<29 wGA n=2,966; Term n=445,150

Medicaid-insured infants
<3 months CA
<29 wGA n=2,489; Term n=484,585

3-<6 months CA
<29 wGA n=4,922; Term n=508,984

6-<12 months CA
<29 wGA n=6,882; Term n=697,094

Excluded

CLDP, CHD, cystic fibrosis, immunodeficiency, congenital anomalies of respiratory system, neuromuscular disease, organ transplants, and other neuromuscular, immunological, or genetic conditions

  • Preterm infants born 29-<37 wGA
  • Term infants with major health problems

 

Outcomes Evaluated

  • RSVH during the RSV season were identified based on inpatient medical claims with a diagnosis code indicative of RSV
    • Rates of RSVH were calculated as the number of RSVH per 100 infant-seasons (infant person-time in days divided by 151 [the number of days in the RSV season])

Study Limitations

  • RSVH was identified using diagnosis codes from inpatient claims; confirmatory laboratory results were not available in the commercial and Medicaid claims databases

Among infants <29 wGA vs term infants, relative RSV hospitalization rates increased since 2014

Risk of RSV Hospitalization Rates: Commercially Insured Infants

 

Among infants <29 wGA vs term infants, relative RSV hospitalization rates increased since 2014

Risk of RSV Hospitalization Rates: Medicaid-Insured Infants

 

Goldstein et al conclusions:

The risk of RSV hospitalization among infants <29 wGA vs full-term infants was greater in commercially insured and Medicaid-insured preterm infants since 2014

The greatest percentage increases in relative RSV hospitalization rates occurred among infants
<3 months of age

 

Reference

  1. Goldstein M, Krilov LR, Fergie J, et al. Impact of the 2014 American Academy of Pediatrics guidance on respiratory syncytial virus hospitalization rates for preterm infants <29 weeks gestational age at birth: 2012 to 2016. Poster presented at: Pediatric Academic Societies Meeting 2019; April 27-30, 2019; Baltimore, MD; Poster 525.

CA=chronological age; CLDP=chronic lung disease of prematurity; CHD=congenital heart disease; RSV=respiratory syncytial virus; RSVH=RSV hospitalizations; wGA=weeks gestational age.

Goldstein et al: Among infants <29 wGA, RSV-related hospitalizations have increased since 20141

This study evaluated the risk of RSV hospitalization among infants <29 wGA since 2014¹

Data Source

IBM Watson Health MarketScan® Commercial Claims and Encounters (commercial) and
Medicaid Multi-State (Medicaid) databases 

Patient Identification

Infants <12 months between July 1, 2012, and June 30, 2016

Included

  • Otherwise healthy infants born at <29 wGA
  • Full-term infants without major health problems

Commercially insured infants
<3 months CA
<29 wGA n=1,157; Term n=313,676

3-<6 months CA
<29 wGA n=2,152; Term n=329,770

6-<12 months CA
<29 wGA n=2,966; Term n=445,150

Medicaid-insured infants
<3 months CA
<29 wGA n=2,489; Term n=484,585

3-<6 months CA
<29 wGA n=4,922; Term n=508,984

6-<12 months CA
<29 wGA n=6,882; Term n=697,094

Excluded

CLDP, CHD, cystic fibrosis, immunodeficiency, congenital anomalies of respiratory system, neuromuscular disease, organ transplants, and other neuromuscular, immunological, or genetic conditions

  • Preterm infants born 29-<37 wGA
  • Term infants with major health problems

 

Outcomes Evaluated

  • RSVH during the RSV season were identified based on inpatient medical claims with a diagnosis code indicative of RSV
    • Rates of RSVH were calculated as the number of RSVH per 100 infant-seasons (infant person-time in days divided by 151 [the number of days in the RSV season])

Study Limitations

  • RSVH was identified using diagnosis codes from inpatient claims; confirmatory laboratory results were not available in the commercial and Medicaid claims databases

Among infants <29 wGA vs term infants, relative RSV hospitalization rates increased since 2014

Risk of RSV Hospitalization Rates: Commercially Insured Infants

 

Among infants <29 wGA vs term infants, relative RSV hospitalization rates increased since 2014

Risk of RSV Hospitalization Rates: Medicaid-Insured Infants

 

Goldstein et al conclusions:

The risk of RSV hospitalization among infants <29 wGA vs full-term infants was greater in commercially insured and Medicaid-insured preterm infants since 2014

The greatest percentage increases in relative RSV hospitalization rates occurred among infants
<3 months of age

 

Reference

  1. Goldstein M, Krilov LR, Fergie J, et al. Impact of the 2014 American Academy of Pediatrics guidance on respiratory syncytial virus hospitalization rates for preterm infants <29 weeks gestational age at birth: 2012 to 2016. Poster presented at: Pediatric Academic Societies Meeting 2019; April 27-30, 2019; Baltimore, MD; Poster 525.

CA=chronological age; CLDP=chronic lung disease of prematurity; CHD=congenital heart disease; RSV=respiratory syncytial virus; RSVH=RSV hospitalizations; wGA=weeks gestational age.